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James has been suspended for four games due to violating the NFL's substance abuse program, NFL Network's Ian Rapoport reports.
James (hip) carried the ball eight times for 39 yards in the Cards' preseason win over the Raiders on Friday.
James may be losing ground in his battle to make the Cardinals' final roster after both William Powell and Alfonso Smith played well during Friday's preseason game.
James (hip) is expected to miss a week or more of training camp with an abductor muscle injury,
James had five carries for 11 yards and had two receptions for 26 yards in Friday's preseason loss to Washington.