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Ninkovich finished up the 2013 season with a career-high 91 tackles, along with eight sacks and two forced fumbles in 16 starts for the Patriots.
Ninkovich (ankle) is listed as questionable for Sunday's game against the Bills after turning in a limited practice on Friday.
Ninkovich was on the field for 90-of-90 defensive snaps in Sunday's overtime win over the Broncos, ESPN.com reports.
Ninkovich (foot) does not appear on the Patriots' Week 11 practice participation/injury report, the team's official site reports.
Ninkovich suffered a foot injury during Sunday's game and is questionable to return, NFL.com reports.