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Williams will miss the rest of the 2013 season due to a torn pectoral muscle, NFL Network's Ian Rapoport reports.
Williams (illness) finished with a season-high 11 total tackles in Sunday's loss to the Saints.
Williams received the start at middle linebacker in Sunday's opener against the Bengals and accrued three tackles in the win.
Williams and rookie Jon Bostic could both share snaps at middle linebacker in Sunday's season opener, ESPN Chicago reports. "It certainly could (be the way we go)," coach Marc Trestman said. "We're going to leave it wide open in terms of where we are at the end of the week. They're both going to be ready to play middle linebacker and there certainly wouldn't be any reason why we wouldn't want to move them around and in-and-out of the game."
Coach Marc Trestman hopes Williams (calf) will return to practice within 12-to-14 days, ESPN Chicago reports.