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Chamberlain notched his first save of the season Tuesday, but needed to record just one out to do so against the White Sox.
Chamberlain had a rough outing Tuesday, allowing two runs on two hits, including a game-tying home run to Toronto's Dan Johnson.
Chamberlain is a candidate for the setup role with the Tigers this season, Chris Iott of Mlive.com reports.
Chamberlain agreed to a one-year, $2.5 million contract with the Tigers on Thursday, ESPN's Buster Olney reports.