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Desmond turned down a seven-year, $107 million contract extension last offseason, the Washington Post reports.
Nationals manager Matt Williams said "there's a chance" Desmond could miss a game during the NLDS or the postseason to be with his pregnant wife, Adam Kilgore of the Washington Post reports.
Desmond is not in the lineup for the second game of Thursday's doubleheader against the Mets, William Ladson of MLB.com reports.
Desmond left Tuesday's game with lower-back tightness, and it is not believed to be serious, MASN's Dan Kolko reports.
Desmond scored a run and knocked in one RBI against the Mariners on Friday as he went 2-for-5, while hitting his 22nd homer (399 feet) of the season.
Desmond is out of the lineup Thursday against the Diamondbacks, Dan Kolko of MASNsports.com reports.
Desmond was locked in Tuesday, going 3-for-4 with four RBI, a run and a stolen base in a win over the Diamondbacks.
Desmond went 1-for-3 Tuesday with two runs scored, two RBI and his 20th home run of the season.
Desmond went 2-for-5 with his 18th homer, a walk, three RBI and two runs Thursday against the Mets.