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Vargas (elbow) will require Tommy John surgery on his torn UCL, manager Ned Yost confirmed to the Kansas City Star on Wednesday.
Vargas left Tuesday's start due to "left medial elbow pain" and will undergo an MRI on Wednesday, Matthew DeFranks of Sports Radio 810 reports.
Vargas (hip) was activated from the DL and has been confirmed as Tuesday's starter against the Pirates.
Vargas (hip) will return from the DL to start Tuesday's game against the Pirates, Andy McCullough of the KC Star reports.
Vargas (hip) gave up two runs over 5.1 innings in Monday's rehab start for Double-A Northwest Arkansas, Matthew DeFranks of FOX Sports Kansas City reports.
Vargas (hip) will throw a simulated game Thursday, Andy McCullough of the Kansas City Star reports.
Vargas picked up his fifth win with six shutout innings Tuesday against the Twins. He struck out two, walked none, and allowed five hits.
Vargas gave up two runs on eight hits and struck out three in six innings Wednesday against the Indians.