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Qualls earned the save Sunday against the Angels after recording the final two outs in the ninth inning.
Qualls was asked to come in to protect a five-run lead in the eighth inning Tuesday against the Yankees, and he gave up one run on three hits with no strikeouts.
Astros manager Bo Porter said Sunday that he will enter the season with a closer by committee, Brian McTaggart of MLB.com reports.
Qualls gave up a solo home run to Ian Kinsler among two hits allowed during an inning of work Saturday against the Tigers.
Qualls is in a "wide-open" battle for the Astros' closer job with the likes of Jesse Crain, Josh Fields and Matt Albers, Evan Drellich of the Houston Chroncile reports.
Qualls has signed a two-year contract with the Astros that includes a team option for a third season, MLB.com's Brian McTaggart reports.