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Qualls struck out a batter during a scoreless inning of relief Tuesday against Oakland to pick up his fifth hold of the season.
Qualls, who stepped into the closer role Thursday in the absence of Luke Gregerson (personal), earned his fourth save of the season against Toronto.
Qualls will likely step into the closer role temporarily with Luke Gregerson being placed on the Family Medical Emergency List.
Qualls gave up a run during the ninth inning of a tie game against the Rangers on Monday night and took his second loss of the season.
Qualls, who earned a one-out save in his last relief appearance Friday night, retired two batters on five pitches Monday against San Diego to pick up his third hold of the season.
Qualls got a one-out save Friday night, retiring Brett Lawrie on a long fly ball to center field in the 11th inning.
Qualls pitched a perfect ninth Tuesday against Seattle to earn his first save of the season.
Qualls picked up his first hold of the season with a scoreless inning of relief Friday against the Rangers.
Qualls struck out one during a scoreless inning of relief Thursday in his 2015 season debut.
Qualls is slated to open the year in a setup role, with Luke Gregerson named the Astros' closer Tuesday, Brian McTaggart of MLB.com reports.
Astros manager A.J. Hinch isn't ready to announce his closer, Jose de Jesus Ortiz of the Houston Chronicle reports.
Qualls is expected to face competition from Luke Gregerson and Pat Neshek for the Astros' closer role in spring training.