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Santana provided all the offense for the Indians Monday, going 1-for-4 with an RBI single against the Astros.
Santana homered in each game of Thursday's doubleheader, giving him 27 homers for the season.
Santana continued his string of success Sunday as he launched two homers, totaled four RBIs, and recorded three hits during three at bats.
Santana had a big night at the dish Tuesday, going 4-for-5 with two RBI and two runs scored while blasting his 15th home run of the year and adding two doubles in the Indians' 8-2 win over the Twins.
Santana, who started at DH on Tuesday, is fine after jamming his shoulder on a dive Monday, MLB.com reports.
Santana exploded Wednesday with four hits including a home run, a double, two RBI and two runs scored.